BACKGROUND: Human papillomavirus (HPV) vaccination of girls will have relatively little effect on HPV-related disease in men who have sex with men (MSM). We determined HPV prevalence and risk factors in MSM to inform the potential effectiveness of vaccinating MSM. METHODS: Cross-sectional study of 522 MSM aged 18-40 attending a London sexual health clinic who completed a computer-assisted self-interview. Urine and two swabs (anal and penile/scrotal/perianal) were collected and tested using an in-house Luminex-based HPV genotyping system. RESULTS: Prevalence of DNA of the vaccine-preventable HPV types in ano-genital specimens of men was 87/511 (17.0%), 166/511 (32.5%) and 232/511 (45.4%) for the bivalent (HPV16/18), quadrivalent (HPV6/11/16/18) and nonavalent (HPV6/11/16/18/31/33/45/52/58) vaccine types, respectively. A total of 25.1% had one of the quadrivalent types, and 7.4% had 2+ types. Median age at first anal sex was 19 (IQR 17-23) and at first clinic attendance was 24 (IQR 20-27). The increase in the odds of any HPV infection per year of age was 4.7% (95% CI 1.2-8.4). CONCLUSIONS: On the basis of the current infection status, most MSM, even among a high-risk population attending a sexual health clinic, are not currently infected with the vaccine-type HPV. A targeted vaccination strategy for MSM in the UK could have substantial benefits.
A bi woman is into daddy dom/little girl play. But she was incensed to see a warning on Porn Hub comparing her harmless kink to child pornography. Porn Hub is riddled with far darker stuff. Why Porn Hub, why?!!
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Addressing these arguments sequentially, we note, first, that the plain language of the statute, prohibiting material portraying minors engaged in conduct which includes the "lascivious exhibition of the genitals or pubic area of any person, " belies Defendant's first argument. Second, little conjecture is needed to find at least simulated oral-genital intercourse when an adult male is depicted as ejaculating into the mouth of a minor female. Finally, the district court was entitled to consider the Defendant's own descriptions that each girl in each picture was young, and the characteristics of each in the photo suggested young age. The female in picture no. 1 wore braces while the subject in picture no. 2 appeared diminutive in all her bodily proportions. In reviewing the evidence in the light most favorable to the Government, we can only conclude that sufficient evidence exists to support the district court's factual determinations. 2ff7e9595c
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